SYSTEMIC VASCULITIS

Vasculitis is inflammation of blood vessels. Commonly, patients with systemic vasculitis have constitutional symptoms including fever, night sweats and weight loss. Joint and muscle pain is also common in many vasculitic syndromes. The severity of the condition ranges considerably from mild cases to those that are organ or life threatening. We can assess which type and design a treatment strategy.

Uric Acid Buildup

The pain and inflammation of Gout are due to a buildup of uric acid. When uric acid rises above a normal level in your body, the small molecules of uric acid can stick together, which forms crystals. These crystals most commonly form around the joints (such as the big toe) because this is where the blood vessels are the smallest. Additionally, these uric acid crystals form most easily in areas of the body that have a lower temperature, typically areas furthest from the heart and other organs. This is why the big toe and ankle are the most commonly affected areas for gout flares.

Purines and Gout

Purines are chemical compounds made up of nitrogen and carbon; they are produced naturally in our bodies but are also contained in the foods that we eat. We metabolize purines during digestion which creates the byproduct known as uric acid.

In people that do not have gout, the uric acid is reabsorbed and processed out of the body via their urine. When these uric acid levels rise too much, the body cannot keep up with the reabsorption and elimination process, which causes uric acid levels in our blood to rise; this condition is called Hyperuricemia. Individuals are considered to have Hyperuricemia if their uric acid blood level is 7 mg/dL or above.